THE HUMAN GLYCINE RECEPTOR - A NEW PROBE THAT IS LINKED TO THE X-LINKED HYPOPHOSPHATEMIC RICKETS GENE

We undertook linkage analysis in four large North Carolina kindreds with X-linked hypophosphatemic rickets (HYP) using a newly defined polymorphic probe, derived from the 5′ untranslated portion of the human glycine receptor (GLR). Two-point linkage analysis established linkage between GLR and HYP [Z(θ) = 7.91 at θ = 0.07] and confirmed linkage between HYP and DXS41 [Z(θ) = 8.31 at θ = 0.06] and DXS43 [Z(θ) = 5.94 at θ = 0.05]. Additionally, we found GLR tightly linked to DXS43 [Z(θ) = 5.40 at θ = 0.0]. Multipoint analysis indicated that GLR is on the telomeric side of HYP with a map order of Xpcen-DXS41-HYP-( GLR DXS43). © 1990.