MALABSORPTION OF HYDROCHLOROTHIAZIDE FOLLOWING INTESTINAL SHUNT SURGERY

被引：33

作者：

BACKMAN, L

BEERMAN, B

GROSCHINSKYGRIND, M

HALLBERG, D

机构：

[1] SERAFIMER HOSP,DEPT MED,S-11283 STOCKHOLM,SWEDEN

[2] SERAFIMER HOSP,CLIN PHARMACOL LAB,S-11283 STOCKHOLM,SWEDEN

来源：

CLINICAL PHARMACOKINETICS | 1979年 / 4卷 / 01期

关键词：

D O I：

10.2165/00003088-197904010-00006

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hydrochlorothiazide 775mg was administered orally to 5 patients who had undergone intestinal shunt operations for obesity 1.5 to 6 years previously. Postoperative weight loss averaged 53.4kg. The concentrations of hydrochlorothiazide in plasma and urine were determined with gas/liquid chromatography. The mean area under the plasma concentration time curve during 9h in 4 of the patients was 889ng/ml · h. Mean total urinary recovery of hydrochlorothiazide amounted to 23.0mg in the 5 patients, which corresponds to approximately half that seen in healthy volunteers. The gastrointestinal hydrochlorothiazide appears to be substantially reduced after intestinal shunt surgery. © 1979, ADIS Press Australasia Pty Ltd.. All rights reserved.

引用

页码：63 / 68

页数：6

共 13 条

[1] DRUG ABSORPTION AND HEPATIC DRUG-METABOLISM IN PATIENTS WITH DIFFERENT TYPES OF INTESTINAL SHUNT OPERATION FOR OBESITY - STUDY WITH PHENAZONE [J].