DRUGS BY DESIGN

被引：35
作者：
BUGG, CE
CARSON, WM
MONTGOMERY, JA
机构：
[1] UNIV ALABAMA,CTR MACROMOLEC CRYSTALLOG,COMP GRAPH CORE FACIL,UNIVERSITY,AL 35486
[2] UNIV ALABAMA,CTR COMPREHENS CANC,UNIVERSITY,AL 35486
[3] SO RES INST,BIRMINGHAM,AL 35255
来源：
SCIENTIFIC AMERICAN | 1993年 / 269卷 / 06期
关键词：
D O I：
10.1038/scientificamerican1293-92
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Random discovery deserves the credit for many of the important pharmaceutical agents in use today. The future of drug development may take shape differently. Powerful computers and detailed knowledge of the chemical structure of drug targets may enable researchers to create an image of such a target and then work backward to design an appropriate therapeutic molecule.
引用
收藏
页码：92 / 98
页数：7
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PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (24) :11540-11544
[2]  
NAVIA MA, 1992, CURR OPIN STRUC BIOL, V2, P202
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