COMPARISON OF 2 MEDICATIONS IN CENTRAL-NERVOUS-SYSTEM TOXOPLASMOSIS IN PATIENTS WITH AIDS

被引：6

作者：

ANTINORI, A

AMMASSARI, A

MAIURO, G

CAMILLI, G

DAMIANO, F

FEDERICO, G

PIZZIGALLO, E

TAMBURRINI, E

机构：

[1] Istituto di Clinica delle Malattie Infettive, Università Cattolica del Sacro Cuore, Roma, 8-00168, Largo Gemelli

[2] Cattedra di Malattie Infettive, Università 'G. D'Annunzio', Chieti

来源：

ITALIAN JOURNAL OF NEUROLOGICAL SCIENCES | 1992年 / 13卷 / 06期

关键词：

TOXOPLASMOSIS; PYRIMETHAMINE; SULFADIAZINE;

D O I：

10.1007/BF02230867

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We retrospectively examined 39 patients with AIDS and central nervous system toxoplasmosis in order to determine the efficacy and safety of two combinations: pyrimethamine-sulfadiazine and pyrimethamine-clindamycin. The results showed a response rate of 79% for the sulfadiazine association and a high failure rate in the clindamycin group. Side effects with sulfadiazine were slightly more frequent, but with desensitization protocols discontinuation was kept down. The combination of pyrimethamine and sulfadiazine, associated, when necessary, with desensitization schedules, was confirmed to be first choice therapy for cerebral toxoplasmosis in AIDS patients. The role of alternative regimens needs further evaluation.

引用

页码：475 / 479

页数：5

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