A SIMPLE STRATEGY FOR OBTAINING BOTH ENANTIOMERS FROM AN ALDOLASE REACTION - PREPARATION OF L-4-HYDROXY-2-KETOGLUTARATE AND D-4-HYDROXY-2-KETOGLUTARATE

被引：11

作者：

FLOYD, NC ^{[1
]}

LIEBSTER, MH ^{[1
]}

TURNER, NJ ^{[1
]}

机构：

[1] UNIV EXETER,DEPT CHEM,STOCKER RD,EXETER EX4 4RJ,DEVON,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 09期

关键词：

D O I：

10.1039/p19920001085

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Both L-(> 95% e.e.) and D-(60% e.e.) 4-hydroxy-2-ketoglutarate 3 have been prepared on a mmol scale using 4-hydroxy-2-ketoglutarate (HKG) aldolase. Substrate specificity studies indicate that HKG aldolase isolated from different sources (Escherichia coli, bovine liver and rat liver) is highly specific for both pyruvate and glyoxylate.

引用

页码：1085 / 1086

页数：2

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