HTLV-I ASSOCIATED ARTHRITIS - CHARACTERISTICS OF AN HTLV-I VIRUS-INFECTED T-CELL LINE FROM SYNOVIAL-FLUID

被引:14
作者
EGUCHI, K [1 ]
NAKAMURA, T [1 ]
MINE, M [1 ]
IDA, H [1 ]
KAWAKAMI, A [1 ]
MIGITA, K [1 ]
NAGASATO, K [1 ]
KURATA, A [1 ]
FUKUDA, T [1 ]
NAGATAKI, S [1 ]
机构
[1] ISAHAYA HLTH INSURANCE HOSP,DEPT INTERNAL MED,NAGASAKI,JAPAN
关键词
D O I
10.1136/ard.51.5.673
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
A T cell line from mononuclear cells in the synovial fluid of a patient with polyarthritis was established. The T cell line reacted with serum samples positive for antibodies to human T cell lymphotropic virus type I (HTLV-I) and with monoclonal antibody to HTLV-I p19. In Southern blotting with an env-pX-LTR HTLV-I probe and digestion of T cell line DNA with the restriction enzymes ClaI, DraI, and PstI generated fragments that were identical to those found in two HTLV-I infected T cell lines established from adult T cell leukaemia or HTLV-I associated myelopathy. The T cell line expressed CD2, CD3, CD4, CD45RA, CD29, HLA-DR, CD25, and CD26 antigens, but not CD8 and CD20 antigens. Large amounts of interleukin 6, interferon-gamma, and tumour necrosis factor-alpha were secreted in the culture supernatants of this cell fine. This line helped immunoglobulin production by B cells, but not K562, Raji, and synovial cell lysis.
引用
收藏
页码:673 / 677
页数:5
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