THE INFLUENCE OF INTRAVENOUS MOLSIDOMINE ON PLATELET-FUNCTION IN ACUTE MYOCARDIAL-INFARCTION

被引：0
作者：
HILLER, E
FISCHER, U
VONESSEN, R
RIESS, H
机构：
[1] STIFTSKLINIKUM AUGUSTINUM,MUNICH,GERMANY
[2] FREE UNIV BERLIN,KLINIKUM RUDOLF VIRCHOW,W-1000 BERLIN 33,GERMANY
来源：
ZEITSCHRIFT FUR KARDIOLOGIE | 1991年 / 80卷
关键词：
MOLSIDOMINE-IV; PLATELET-FUNCTION; BLEEDING TIME; HYPERREACTIVE PLATELETS;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In 10 patients with acute myocardial infarction i.v. molsidomine was given over 48 h and a number of platelet functions was evaluated before and 3, 24, and 48 h after therapy. There was a significant prolongation of template bleeding time from 290 s to 400 s. The amplitude of spontaneous and induced platelet aggregation remained unchanged. In four of the 10 patients initially high plasma concentrations of beta-TG and PF4, and high serum concentrations of TxB2, decreased, indicating an effect of molsidomine in state of hyperreactive platelets.
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页码：59 / 62
页数：4
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