A simple method for N-acylation of adenosine and cytidine nucleosides using carboxylic acids activated in-situ with carbonyldiimidazole

被引：12

作者：

Sinha, ND

Davis, P

Schultze, LM

Upadhya, K

机构：

[1] Applied Biosystems Division, Perkin-Elmer Corporation, Foster City, CA 94404

来源：

TETRAHEDRON LETTERS | 1995年 / 36卷 / 51期

关键词：

D O I：

10.1016/0040-4039(95)02011-D

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Carboxylic acids are activated with 1,1'-carbonyldiimidazole in acetonitrile to form N-acylimidazoles which are then treated with per-trimethylsilyl ethers of nucleosides adenosine or cytidine at ambient temperature to generate exclusively N-acylated-Adenosine or N-acylated-Cytidine derivatives.

引用

收藏

页码：9277 / 9280

页数：4

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