RNA-POLYMERASE I-MEDIATED PROTEIN-CODING GENE-EXPRESSION IN TRYPANOSOMA-BRUCEI

被引：51
作者：
CHUNG, HM
LEE, MGS
VANDERPLOEG, LHT
机构：
[1] COLUMBIA UNIV, DEPT GENET & DEV, NEW YORK, NY 10032 USA
[2] COLUMBIA UNIV, SCH PUBL HLTH, DIV TROP MED, NEW YORK, NY 10032 USA
来源：
PARASITOLOGY TODAY | 1992年 / 8卷 / 12期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/0169-4758(92)90194-7
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Protein-coding genes are transcribed by RNA polymerase (pol) II in all eukaryotes analyzed to date, with the exception of the protozoan Trypanosoma brucei, where pol I can mediate expression of chloramphenicol acetyl transferase (CAT) and neomycin phosphotransferase (neo) reporter genes. The addition of the capped 39-nucleotide (nt) mini-exon to the pre-messenger RNA (mRNA) by trans-splicing in T. brucei has presumably led to the uncoupling of the requirement for production of mRNA by pol II. Here Hui-min Chung Mary G-S. Lee and Lex Van der Ploeg review the evidence that supports the notion that pol I also transcribes a subset of naturally occurring protein-coding genes in T. brucei.
引用
收藏
页码：414 / 418
页数：5
相关论文
共 43 条
[1]   TRANSSPLICING OF NUCLEAR PRE-MESSENGER-RNAS [J].
AGABIAN, N .
CELL, 1990, 61 (07) :1157-1160
[2]   DISCONTINUOUS TRANSCRIPTION AND ANTIGENIC VARIATION IN TRYPANOSOMES [J].
BORST, P .
ANNUAL REVIEW OF BIOCHEMISTRY, 1986, 55 :701-732
[3]   THE PROMOTER FOR THE PROCYCLIC ACIDIC REPETITIVE PROTEIN (PARP) GENES OF TRYPANOSOMA-BRUCEI SHARES FEATURES WITH RNA POLYMERASE-I PROMOTERS [J].
BROWN, SD ;
HUANG, J ;
VANDERPLOEG, LHT .
MOLECULAR AND CELLULAR BIOLOGY, 1992, 12 (06) :2644-2652
[4]   ARCHITECTURAL ORGANIZATION IN THE INTERPHASE NUCLEUS OF THE PROTOZOAN TRYPANOSOMA-BRUCEI - LOCATION OF TELOMERES AND MINICHROMOSOMES [J].
CHUNG, HMM ;
SHEA, C ;
FIELDS, S ;
TAUB, RN ;
VANDERPLOEG, LHT .
EMBO JOURNAL, 1990, 9 (08) :2611-2619
[5]   TRANSCRIPTION OF THE PROCYCLIC ACIDIC REPETITIVE PROTEIN GENES OF TRYPANOSOMA-BRUCEI [J].
CLAYTON, CE ;
FUERI, JP ;
ITZHAKI, JE ;
BELLOFATTO, V ;
SHERMAN, DR ;
WISDOM, GS ;
VIJAYASARATHY, S ;
MOWATT, MR .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (06) :3036-3047
[6]   TRANSCRIPTION ANALYSIS IN TRYPANOSOMA-BRUCEI [J].
CORNELISSEN, AWCA ;
BACKES, S ;
EVERS, R ;
GRONDAL, EJM ;
JESS, W ;
KOCK, J .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1990, 18 (05) :710-714
[7]  
CORNELISSEN AWCA, 1989, ACTA LEIDENSIA, V58, P2
[8]   STABLE INTEGRATIVE TRANSFORMATION OF TRYPANOSOMA-BRUCEI THAT OCCURS EXCLUSIVELY BY HOMOLOGOUS RECOMBINATION [J].
EID, J ;
SOLLNERWEBB, B .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1991, 88 (06) :2118-2121
[9]   TRYPANOSOMA BRUCEI CONTAINS 2 RNA POLYMERASE-II LARGEST SUBUNIT GENES WITH AN ALTERED C-TERMINAL DOMAIN [J].
EVERS, R ;
HAMMER, A ;
KOCK, J ;
JESS, W ;
BORST, P ;
MEMET, S ;
CORNELISSEN, AWCA .
CELL, 1989, 56 (04) :585-597
[10]   TRANSCRIPTION BY RNA POLYMERASE-III [J].
GEIDUSCHEK, EP ;
TOCCHINIVALENTINI, GP .
ANNUAL REVIEW OF BIOCHEMISTRY, 1988, 57 :873-914
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