CHRONIC DESIPRAMINE ENHANCES THE EFFECT OF LOCALLY APPLIED AMPHETAMINE ON INTERSTITIAL CONCENTRATIONS OF DOPAMINE IN THE NUCLEUS-ACCUMBENS

被引：18
|
作者：
BROWN, EE [1 ]
NOMIKOS, GG [1 ]
WILSON, C [1 ]
FIBIGER, HC [1 ]
机构：
[1] UNIV BRITISH COLUMBIA,DEPT PSYCHIAT,DIV NEUROL SCI,VANCOUVER V6T 1Z3,BC,CANADA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1991年 / 202卷 / 01期
关键词：
DESIPRAMINE; DOPAMINE; AMPHETAMINE; MICRODIALYSIS; NUCLEUS ACCUMBENS;
D O I：
10.1016/0014-2999(91)90266-S
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
In vivo microdialysis was used to study the effect of chronic desipramine (DMI, 5 mg/kg, twice daily for 21 days) on increases in interstitial dopamine (DA) produced by local administration of d-amphetamine (1.0, 3.3 and 10.0-mu-M) in the nucleus accumbens. Locally applied amphetamine increased interstitial DA in a dose-dependent manner. The amphetamine-induced increase was significantly greater in the DMI treated animals. These data suggest that chronic DMI may directly influence the functional status of the DA terminals in the nucleus accumbens.
引用
收藏
页码：125 / 127
页数：3
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