EFFECTS OF 3'-DEOXYADENOSINE (CORDYCEPIN) ON THE REPAIR OF X-RAY-INDUCED DNA SINGLE-STRAND AND DOUBLE-STRAND BREAKS IN CHINESE HAMSTER V79 CELLS

被引:4
作者
HIRAOKA, W
KUWABARA, M
SATO, F
机构
[1] Department of Radiation Biology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo
关键词
D O I
10.1269/jrr.31.156
中图分类号
Q [生物科学];
学科分类号
07 ; 0710 ; 09 ;
摘要
Cordycepin/3’-deoxyadenosine/DSB/SSB/DNA repair The ability of cordycepin to inhibit the repair of DNA strand breaks was examined with X-irradiated Chinese hamster V79 cells in log-phase culture. A filter elution technique revealed that 70μM cordycepin did not inhibit the repair of single-strand breaks but inhibited the repair of double-strand breaks. These findings confirmed the fact that the increase in the lethality of cordycepin in X-irradiated cultured mammalian cells was attributable to unrepaired DNA double-strand breaks. © 1990, Journal of Radiation Research Editorial Committee. All rights reserved.
引用
收藏
页码:156 / 161
页数:6
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