EFFECTS OF 3'-DEOXYADENOSINE (CORDYCEPIN) ON THE REPAIR OF X-RAY-INDUCED DNA SINGLE-STRAND AND DOUBLE-STRAND BREAKS IN CHINESE HAMSTER V79 CELLS

被引：4
作者：
HIRAOKA, W
KUWABARA, M
SATO, F
机构：
[1] Department of Radiation Biology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo
来源：
JOURNAL OF RADIATION RESEARCH | 1990年 / 31卷 / 02期
关键词：
D O I：
10.1269/jrr.31.156
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Cordycepin/3’-deoxyadenosine/DSB/SSB/DNA repair The ability of cordycepin to inhibit the repair of DNA strand breaks was examined with X-irradiated Chinese hamster V79 cells in log-phase culture. A filter elution technique revealed that 70μM cordycepin did not inhibit the repair of single-strand breaks but inhibited the repair of double-strand breaks. These findings confirmed the fact that the increase in the lethality of cordycepin in X-irradiated cultured mammalian cells was attributable to unrepaired DNA double-strand breaks. © 1990, Journal of Radiation Research Editorial Committee. All rights reserved.
引用
收藏
页码：156 / 161
页数：6
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