GAS-CHROMATOGRAPHIC DETERMINATION OF PENTETRAZOLE IN BLOOD AND BRAIN OF RATS AND BLOOD OF HUMANS

被引：0

作者：

DALBO, L ^{[1
]}

MARCUCCI, F ^{[1
]}

MUSSINI, E ^{[1
]}

机构：

[1] IST RIC FARMACOL MARIO NEGRI,I-20157 MILAN,ITALY

来源：

JOURNAL OF PHARMACOLOGICAL METHODS | 1979年 / 2卷 / 01期

关键词：

Blood and brain levels in rats; Blood levels in humans; GLC assay; Pentetrazole;

D O I：

10.1016/0160-5402(79)90013-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

A GLC method has been developed that is sufficiently sensitive to detect pentetrazole (PNZ) in human blood after clinical therapeutic doses. The assay involves a single extraction of PNZ into benzene followed by centrifugation, evaporation, and gas chromatography using a nitrogen phosphorus selective detector. The sensitivity limit is 0.1 μg of PNZ/ml of biological sample. The method has been used to determine blood and brain levels of PNZ in rats, and blood concentrations in humans orally treated with the drug. © 1979.

引用

页码：29 / 33

页数：5

共 6 条

[1] PHARMACOKINETIC STUDIES OF PENTYLENETETRAZOL IN DOGS [J].