BOTH SPLICING VARIANTS OF THE DOPAMINE-D2 RECEPTOR MESSENGERRNA ARE UP-REGULATED BY ANTIPSYCHOTIC-DRUGS

被引：16
作者：
BUCKLAND, PR
ODONOVAN, MC
MCGUFFIN, P
机构：
[1] Department of Psychological Medicine, University of Wales College of Medicine, Cardiff
来源：
NEUROSCIENCE LETTERS | 1993年 / 150卷 / 01期
关键词：
DOPAMINE-D2 GENE EXPRESSION; MESSENGER RNA MEASUREMENT; ALTERNATIVE SPLICING; ANTIPSYCHOTIC; SOLUTION HYBRIDIZATION;
D O I：
10.1016/0304-3940(93)90099-7
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We have investigated the effects of antipsychotic drugs on the expression of the two dopamine D2 receptor splicing variants using multiprobe oligonucleotide solution hybridisation. Both long and short mRNA variants were increased in abundance by approximately 2-fold by both haloperidol and loxapine after 32 days drug administration.
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页码：25 / 28
页数：4
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