INFLUENCE OF NALOXONE UPON MOTOR-ACTIVITY INDUCED BY PSYCHOMOTOR STIMULANT-DRUGS

被引:33
作者
JONES, DNC [1 ]
HOLTZMAN, SG [1 ]
机构
[1] EMORY UNIV, SCH MED, DEPT PHARMACOL, ATLANTA, GA 30322 USA
关键词
AMPHETAMINE; COCAINE; OPIOID ANTAGONIST; NALOXONE; CATECHOLAMINE UPTAKE INHIBITORS; CATECHOLAMINE RELEASING AGENTS; PSYCHOMOTOR STIMULANTS; MOTOR ACTIVITY;
D O I
10.1007/BF02244839
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Naloxone, an opioid receptor antagonist, attenuates a wide range of behavioral effects of d-amphetamine, such as the stimulation of motor activity. To investigate the pharmacological selectivity of the naloxone/amphetamine interaction, we assessed the effects of naloxone (5.0 mg/kg SC) upon motor activity induced in rats by a range of psychomotor stimulant drugs with a mechanism of action either similar to or different from that of d-amphetamine. Each of the drugs tested caused dose-dependent increases in bath gross and fine activity. Naloxone attenuated the gross but not the fine activity response to d- and l-amphetamine, but had no influence upon the other catecholamine-releasing drugs, methamphetamine and phendimetrazine. In contrast, naloxone increased the gross but not the fine activity response to the catecholamine uptake inhibitors cocaine and mazindol, but had no effects upon the motor response to methylphenidate. The responses to other stimulant drugs (apomorphine, caffeine, scopolamine) were unaffected by naloxone pretreatment. The present findings extend the range of conditions under which naloxone and, by inference, endogenous opioid systems, modulate the behavioral response to psychomotor stimulants. However, the differential effects of naloxone upon the motor response to individual stimulant drugs support previous suggestions of fundamental differences in mechanisms of action among these compounds.
引用
收藏
页码:215 / 224
页数:10
相关论文
共 82 条
[1]   BLOCKADE OF DELTA-OPIOID RECEPTORS IN THE NUCLEUS-ACCUMBENS PREVENTS ETHANOL-INDUCED STIMULATION OF DOPAMINE RELEASE [J].
ACQUAS, E ;
MELONI, M ;
DICHIARA, G .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1993, 230 (02) :239-241
[2]   POTENTIATION OF APOMORPHINE AND D-AMPHETAMINE EFFECTS BY NALOXONE [J].
ADAMS, PM ;
BEAUCHAMP, R ;
ALSTON, C .
LIFE SCIENCES, 1981, 28 (06) :629-634
[3]   THE INTERACTION OF D-AMPHETAMINE AND NALOXONE DIFFERS FOR RATS TRAINED ON SEPARATE FIXED-INTERVAL OR FIXED-RATIO SCHEDULES OF REINFORCEMENT [J].
ANDREWS, JS ;
HOLTZMAN, SG .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1987, 26 (01) :167-171
[4]   EFFECTS OF NALOXONE AND DIPRENORPHINE ON AMPHETAMINE-STIMULATED BEHAVIOR IN GUINEA-PIGS AND RATS [J].
ANDREWS, JS ;
HOLTZMAN, SG .
NEUROPHARMACOLOGY, 1987, 26 (08) :1115-1120
[5]   DOPAMINE RELEASE AND METABOLISM IN THE RAT STRIATUM - AN ANALYSIS BY INVIVO BRAIN MICRODIALYSIS [J].
ARBUTHNOTT, GW ;
FAIRBROTHER, IS ;
BUTCHER, SP .
PHARMACOLOGY & THERAPEUTICS, 1990, 48 (03) :281-293
[6]   NALOXONE ATTENUATION OF THE EFFECT OF COCAINE ON REWARDING BRAIN-STIMULATION [J].
BAIN, GT ;
KORNETSKY, C .
LIFE SCIENCES, 1987, 40 (11) :1119-1125
[7]  
BALSARA JJ, 1984, PSYCHOPHARMACOLOGY, V82, P237, DOI 10.1007/BF00427781
[8]   THE SUBSTITUTED AMPHETAMINES 3,4-METHYLENEDIOXYMETHAMPHETAMINE, METHAMPHETAMINE, PARA-CHLOROAMPHETAMINE AND FENFLURAMINE INDUCE 5-HYDROXYTRYPTAMINE RELEASE VIA A COMMON MECHANISM BLOCKED BY FLUOXETINE AND COCAINE [J].
BERGER, UV ;
GU, XF ;
AZMITIA, EC .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1992, 215 (2-3) :153-160
[9]  
BERKOWITZ BA, 1975, J PHARMACOL EXP THER, V195, P499
[10]   OPIOIDERGIC MODULATION OF COCAINE CONDITIONED PLACE PREFERENCES [J].
BILSKY, EJ ;
MONTEGUT, MJ ;
DELONG, CL ;
REID, LD .
LIFE SCIENCES, 1992, 50 (14) :PL85-PL90