CONVERGENT SYNTHESIS OF THE STREPTONIGRIN ALKALOID SKELETON - DIRECTED ORTHOMETALATION CONNECTION TO ARYL-ARYL CROSS-COUPLING

被引：40

作者：

GODARD, A

ROVERA, JC

MARSAIS, F

PLE, N

QUEGUINER, G

机构：

[1] Laboratoire de Chimie Organique Fine et Hétérocyclique de l'IRCOF, URA 1429, Institut National des Sciences Appliquées de Rouen, 76131 Mont-Saint-Aignan Cedex

来源：

TETRAHEDRON | 1992年 / 48卷 / 20期

关键词：

STREPTONINGRIN; ALKALOID; METALATION; PALLADIUM; COUPLING;

D O I：

10.1016/S0040-4020(01)92191-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convergent synthesis of 2-[2-(4-phenyl-3-pivaloylamino) pyridyl]quinolines, the streptonigrin alkaloid skeleton, is reported. The methodology involves independent elaboration of the three main building blocks by metalation and two coupling reactions catalyzed by palladium.

引用

页码：4123 / 4134

页数：12

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