BRAIN BETA-ADRENOCEPTOR BINDING-SITES IN DEPRESSED SUICIDE VICTIMS - EFFECTS OF ANTIDEPRESSANT TREATMENT

被引：32
作者：
DEPAERMENTIER, F
CHEETHAM, SC
CROMPTON, MR
KATONA, CLE
HORTON, RW
机构：
[1] ST GEORGE HOSP,SCH MED,DEPT FORENS MED,LONDON SW17 0RE,ENGLAND
[2] UNIV COLL & MIDDLESEX SCH MED,DEPT PSYCHIAT,LONDON W1A 8AA,ENGLAND
来源：
PSYCHOPHARMACOLOGY | 1991年 / 105卷 / 02期
关键词：
DEPRESSION; SUICIDE; POSTMORTEM HUMAN BRAIN; BETA-ADRENOCEPTORS; (H-3)CGP 12177; ANTIDEPRESSANT DRUG;
D O I：
10.1007/BF02244323
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Beta-Adrenoceptor binding sites were measured by saturation binding of [H-3]CGP 12177 in nine brain regions from 13 suicides, with a firm retrospective diagnosis of depression, who had been receiving antidepressant drugs, and 11 matched controls. Significantly lower numbers of beta-adrenoceptor binding sites were found in thalamus and temporal cortex (Brodmann area 38), but not in other brain regions, of antidepressant-treated suicides compared to controls. The lower number of beta-adrenoceptor binding sites in thalamus appeared to be related to drug treatment, whereas lower numbers of beta-adrenoceptors in temporal cortex were also found in antidepressant-free suicides.
引用
收藏
页码：283 / 288
页数：6
相关论文
共 24 条
[1]   THE EFFECT OF RAPID EYE-MOVEMENT SLEEP-DEPRIVATION ON CORTICAL BETA-ADRENERGIC RECEPTORS [J].
ABEL, MS ;
VILLEGAS, F ;
ABREU, J ;
GIMINO, F ;
STEINER, S ;
BEER, B ;
MEYERSON, LR .
BRAIN RESEARCH BULLETIN, 1983, 11 (06) :729-734
[2]   DEVELOPMENT OF BETA-ADRENERGIC-RECEPTOR SUBSENSITIVITY BY ANTIDEPRESSANTS [J].
BANERJEE, SP ;
KUNG, LS ;
RIGGI, SJ ;
CHANDA, SK .
NATURE, 1977, 268 (5619) :455-456
[3]   EFFECT OF ELECTROCONVULSIVE SHOCK ON MONO-AMINERGIC RECEPTOR-BINDING SITES IN RAT-BRAIN [J].
BERGSTROM, DA ;
KELLAR, KJ .
NATURE, 1979, 278 (5703) :464-466
[4]   DETERMINATION OF MONOAMINE AND MONOAMINE METABOLITES IN HUMAN BRAIN - POST-MORTEM STUDIES IN A GROUP OF SUICIDES AND IN A CONTROL GROUP [J].
BESKOW, J ;
GOTTFRIES, CG ;
ROOS, BE ;
WINBLAD, B .
ACTA PSYCHIATRICA SCANDINAVICA, 1976, 53 (01) :7-20
[5]  
BIEGON A, 1986, J NEUROCHEM, V47, P77
[6]   REGIONALLY SELECTIVE INCREASES IN BETA-ADRENERGIC-RECEPTOR DENSITY IN THE BRAINS OF SUICIDE VICTIMS [J].
BIEGON, A ;
ISRAELI, M .
BRAIN RESEARCH, 1988, 442 (01) :199-203
[7]   BRAIN 5-HT2 RECEPTOR-BINDING SITES IN DEPRESSED SUICIDE VICTIMS [J].
CHEETHAM, SC ;
CROMPTON, MR ;
KATONA, CLE ;
HORTON, RW .
BRAIN RESEARCH, 1988, 443 (1-2) :272-280
[8]   ADRENERGIC-RECEPTORS IN DEPRESSION EFFECTS OF ELECTROCONVULSIVE-THERAPY [J].
COOPER, SJ ;
KELLY, JG ;
KING, DJ .
BRITISH JOURNAL OF PSYCHIATRY, 1985, 147 (JUL) :23-29
[9]   BETA-ADRENOCEPTORS IN HUMAN-BRAIN LABELED WITH [H-3] DIHYDROALPRENOLOL AND [H-3] CGP-12177 [J].
DEPAERMENTIER, F ;
CHEETHAM, SC ;
CROMPTON, MR ;
HORTON, RW .
EUROPEAN JOURNAL OF PHARMACOLOGY, 1989, 167 (03) :397-405
[10]   BRAIN BETA-ADRENOCEPTOR BINDING-SITES IN ANTIDEPRESSANT-FREE DEPRESSED SUICIDE VICTIMS [J].
DEPAERMENTIER, F ;
CHEETHAM, SC ;
CROMPTON, MR ;
KATONA, CLE ;
HORTON, RW .
BRAIN RESEARCH, 1990, 525 (01) :71-77
123