DIFFERENTIAL EFFECT OF BETA-ENDORPHIN ON 3 HUMAN CYTOTOXIC-CELL POPULATIONS

被引：24

作者：

CHIAPPELLI, F

YAMASHITA, N

FAISAL, M

KEMENY, M

BULLINGTON, R

NGUYEN, L

CLEMENT, LT

FAHEY, JL

机构：

[1] UNIV CALIF LOS ANGELES,PSYCHONEUROIMMUNOL PROGRAM,LOS ANGELES,CA 90024

[2] UNIV CALIF LOS ANGELES,DEPT MICROBIOL & IMMUNOL,LOS ANGELES,CA 90024

[3] UNIV CALIF LOS ANGELES,BRAIN RES INST,LOS ANGELES,CA 90024

[4] UNIV CALIF LOS ANGELES,DEPT PSYCHIAT & BIOBEHAV SCI,LOS ANGELES,CA 90024

[5] UNIV CALIF LOS ANGELES,DEPT PEDIAT,LOS ANGELES,CA 90024

[6] COLL WILLIAM & MARY,GLOUCESTER POINT,VA 23062

来源：

INTERNATIONAL JOURNAL OF IMMUNOPHARMACOLOGY | 1991年 / 13卷 / 2-3期

关键词：

D O I：

10.1016/0192-0561(91)90110-S

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We have examined in vitro the effect of the proopiomelanocortin gene product, beta-endorphin (bE), on the cytoxic activity of natural killer (NK) cells, lymphokine activated killer (LAK) cells and cytotoxic T-lymphocytes (CTL). Our studies show that bE reproducibly suppressed LAK cytotoxic activity in all donors tested. The effect of bE on the generation of CTL varied, and was negligible on CTL cytotoxic function. Our study also confirms the variable nature of the effects of bE on NK cytotoxicity. In all instances, the effects of bE were generally small, but could be blocked by opioid receptor antagonists, or by prior heat-inactivation of the peptide. The magnitude of the effects was greatest at low effector:target ratios in all of the three systems studied. These results support the emerging body of evidence that the neuroendocrine system may influence host defense mechanisms mediated by cytotoxic cells.

引用

页码：291 / 297

页数：7

共 25 条

[21] SPONTANEOUS HUMAN LYMPHOCYTE-MEDIATED CYTO-TOXICITY AGAINST TUMOR TARGET-CELLS .9. THE QUANTITATION OF NATURAL-KILLER CELL-ACTIVITY [J].