Microhaplotype loci are a powerful new type of forensic marker

被引：107

作者：

Kidd, K. K. ^{[1
]}

Pakstis, A. J. ^{[1
]}

Speed, W. C. ^{[1
]}

Lagace, R. ^{[2
]}

Chang, J. ^{[2
]}

Wootton, S. ^{[2
]}

Ihuegbu, N. ^{[2
]}

机构：

[1] Yale Univ, Sch Med, Genet Dept, 333 Cedar St, New Haven, CT 06520 USA

[2] Life Technol, Human Identificat Grp, Foster City, CA 94404 USA

来源：

FORENSIC SCIENCE INTERNATIONAL GENETICS SUPPLEMENT SERIES | 2013年 / 4卷 / 01期

关键词：

SNP; Haplotype; Sequencing; Polymorphism; Ancestry;

D O I：

10.1016/j.fsigss.2013.10.063

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

6Modern sequencing technology makes it possible to genotype polymorphisms with high throughput and high multiplexing. We have searched for and identified many loci with 2 or more SNPs within the expanse of a 200 bp single sequence run and show that when linkage disequilibrium is not complete these loci have multiple alleles detected as phase-known haplotypes. These microhaplotype loci (microhaps) are a powerful tool for individual identification, ancestry inference, and determining family/clan relationships. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：E123 / E124

页数：2

共 3 条

[1]

Pakstis A.J., Fang R., Furtado M.R., Kidd J.R., Kidd K.K., Mini-haplotypes as lineage informative SNPs (LISNPs) and ancestry inference SNPs (AISNPs), Eur. J. Hum. Gen., 20, pp. 1148-1154, (2012)

[2]

Kidd K.K., Kidd J.R., Speed W.C., Fang R., Furtado M.R., Hyland F.C., Pakstis A.J., Expanding data and resources for forensic use of SNPs in individual identification, Forensic Sci. Int. Genet., 6, pp. 646-652, (2012)

[3]

Li J.Z., Absher D.M., Tang H., Southwick A.M., Casto A.M., Ramachandran S., Cann H.M., Barsh G.S., Et al., Worldwide human relationships inferred from genome-wide patterns of variation, Science, 319, pp. 1100-1104, (2008)

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