AXIAL TO RADIAL PRESSURE TRANSMISSION OF TABLET EXCIPIENTS USING A NOVEL INSTRUMENTED DIE

被引:7
作者
COCOLAS, HG [1 ]
LORDI, NG [1 ]
机构
[1] RUTGERS UNIV,COLL PHARM,CTR INFORMAT,PISCATAWAY,NJ 08855
关键词
D O I
10.3109/03639049309047197
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
A die instrumented with four piezoelectric force transducers was developed for use on the Rutgers Integrated Compaction Research System. It was calibrated and characterized using high density polyethylene as the calibrating material. Results showed that the radial response measured by the four die wall transducers was dependent upon the thickness of the compact being compressed and its location within the die. These two factors were incorporated into the calibration constant which converted the die wall response from voltage units into pressure units. Sample compaction profiles showing axial to radial pressure transmission of selected materials of interest in tableting were generated using this die.
引用
收藏
页码:2473 / 2497
页数:25
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