HPLC SEPARATION OF TAXOL AND CEPHALOMANNINE

被引：100

作者：

CARDELLINA, JH

机构：

[1] Laboratory of Drug Discovery, Research & Development, National Cancer Institute, Frederick, Maryland, 21702-1201, Building 1052

来源：

JOURNAL OF LIQUID CHROMATOGRAPHY | 1991年 / 14卷 / 04期

关键词：

D O I：

10.1080/01483919108049278

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Taxol [1], a highly functionalized antimitotic diterpene which occurs as a minor component of extracts of the bark from trees of the genus Taxus, is required in increasingly larger quantities for clinical trials. Final purification of taxol requires separation from cephalomannine [2]. An efficient separation of those closely related analogs has been achieved by normal phase HPLC on a cyanopropyl column.

引用

页码：659 / 665

页数：7

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