MUTAGENICITY OF AMINOPHENYL AND NITROPHENYL ETHERS, SULFIDES, AND DISULFIDES

被引：45

作者：

LAVOIE, E

TULLEY, L

FOW, E

HOFFMANN, D

机构：

[1] Division of Environmental Carcinogenesis, Naylor Dana Institute for Disease Prevention, American Health Foundation, Valhalla

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 02期

关键词：

D O I：

10.1016/0165-1218(79)90123-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The mutagenic activity of several aromatic amines and aromatic nitro compounds related to 4,4′-methylenedianiline towards Salmonella typhymurium tester strains TA100 and TA98 was evaluated. The heteroatomic analogs of 4,4′-methylenedianiline which include aminophenyl and nitrophenyl ethers, sulfides and disulfides were assayed in the presence of rat-liver homogenate. The relative mutagenic response of these analogs indicated the following order of activity, S > O > CH2CH2 {slanted equal to or greater-than} SS. In both tester strains 4-aminophenylsulfone was inactive with and without microsomal activation. The p-nitrophenyl ethers, sulfides and disulfides were relatively strong mutagens without microsomal activation towards TA100. While 4-nitrophenyldisulfide was found to possess significantly different mutagenic activity than 4-nitrothiophenol in TA98, 4-aminophenyl disulfide has similar mutagenic properties to 4-aminothiophenol in both tester strains TA100 and TA98. © 1979.

引用

页码：123 / 131

页数：9

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