HUMAN GLOMERULAR BASEMENT-MEMBRANE - ANTIGENIC DETERMINANTS IN HUMAN-URINE

被引：3

作者：

BYGREN, P ^{[1
]}

WIESLANDER, J ^{[1
]}

HEINEGARD, D ^{[1
]}

机构：

[1] UNIV LUND,DEPT PHYSIOL CHEM,S-22007 LUND 7,SWEDEN

来源：

BIOCHIMICA ET BIOPHYSICA ACTA | 1979年 / 553卷 / 02期

关键词：

(Glomerular basement membrane); Antigenic determinant; Urinary antigen;

D O I：

10.1016/0005-2736(79)90230-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Antisera against particulate human glomerular basement membrane prepared from cadaver kidneys were raised in rabbits. It was shown that both normal individuals and patients with glomerular and tubular diseases excrete in their urine several antigens reactive with these antibodies. One antigen crossreacted immunologically with an antigen from human glomerular basement membrane while several others did not. One of the urinary antigens and the antigen crossreacting with the basement membrane were separated from the others by ion exchange chromatography and gel filtration, respectively. The pattern of antigen excretion differed depending on the underlying renal disease but the multitude of different antigens detected complicates the interpretation of the patterns of excretion in different diseases. © 1979.

引用

页码：255 / 261

页数：7

共 9 条

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[9] HUMAN GLOMERULAR BASEMENT-MEMBRANE - HETEROGENEITY OF ANTIGENIC DETERMINANTS
WIESLANDER, J
BYGREN, P
HEINEGARD, D
[J]. BIOCHIMICA ET BIOPHYSICA ACTA, 1979, 553 (02) : 244 - 254

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