PROTEIN KINASE-C(19-31) PSEUDOSUBSTRATE INHIBITION OF INSULIN ACTION IN RAT ADIPOCYTES

被引：10
|
作者：
STANDAERT, ML
SASSE, J
COOPER, DR
FARESE, RV
机构：
[1] UNIV S FLORIDA,DEPT INTERNAL MED,TAMPA,FL 33612
[2] UNIV S FLORIDA,DEPT BIOCHEM MOLEC BIOL,TAMPA,FL 33612
来源：
FEBS LETTERS | 1991年 / 282卷 / 01期
关键词：
INSULIN; PROTEIN KINASE-C; HEXOSE UPTAKE; ADIPOCYTE;
D O I：
10.1016/0014-5793(91)80463-D
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19-31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC50 values of 30-mu-M and 600-mu-M for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.
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页码：139 / 142
页数：4
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