RECOMBINANT ALPHA-INTERFERON TREATMENT OF NON-A, NON-B (TYPE-C) HEPATITIS - REVIEW OF STUDIES AND RECOMMENDATIONS FOR TREATMENT

被引:49
作者
DAVIS, GL
机构
[1] Department of Medicine, University of Florida College of Medicine, Cainesville, FL
关键词
D O I
10.1016/0168-8278(90)90168-Q
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Non-A, non-B (type C) hepatitis is a serious world problem which typically results in chronic hepatitis and may lead to cirrhosis and hepatocellular carcinoma. alpha-Interferon has recently been studied in a number of randomized controlled trials throughout the world. The results of those studies are reviewed here. ALT levels were normalized by 2-3 MU recombinant interferon alfa-2b, three times per week s.c. for 6 months (p < 0.001 vs. control) in 36% of patients in five trials. Biopsy tests also demonstrated histological improvement in lobular and periportal inflammation. Unfortunately, relapse is a common problem in these studies, occurring in 49% of patients treated with 3 million units and 57% of those treated with 1 million units. Retreatment usually brings remission once again. In the future, long-term studies will further elucidate the natural history of the disease and documented guidelines for interferon dosage and duration of dosing in a wider range of patient subgroups will become available.
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页码:S72 / S77
页数:6
相关论文
共 24 条
[2]  
COLOMBO M, 1989, LANCET, V2, P1006
[3]   TREATMENT OF CHRONIC HEPATITIS-C WITH RECOMBINANT INTERFERON-ALFA - A MULTICENTER RANDOMIZED, CONTROLLED TRIAL [J].
DAVIS, GL ;
BALART, LA ;
SCHIFF, ER ;
LINDSAY, K ;
BODENHEIMER, HC ;
PERRILLO, RP ;
CAREY, W ;
JACOBSON, IM ;
PAYNE, J ;
DIENSTAG, JL ;
VANTHIEL, DH ;
TAMBURRO, C ;
LEFKOWITCH, J ;
ALBRECHT, J ;
MESCHIEVITZ, C ;
ORTEGO, TJ ;
GIBAS, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (22) :1501-1506
[4]   NON-A, NON-B HEPATITIS - EVOLVING EPIDEMIOLOGIC AND CLINICAL PERSPECTIVE [J].
DIENSTAG, JL ;
ALTER, HJ .
SEMINARS IN LIVER DISEASE, 1986, 6 (01) :67-81
[5]  
DIENSTAG JL, 1983, GASTROENTEROLOGY, V85, P439
[6]  
HADLER SC, 1989, VIRAL INFECTIONS HUM
[7]  
HASAN F, 1989, HEPATOLOGY, V10, P608
[8]  
Hoofnagle J H, 1988, Transfus Med Rev, V2, P215, DOI 10.1016/S0887-7963(88)70047-4
[9]   TREATMENT OF CHRONIC NON-A,NON-B HEPATITIS WITH RECOMBINANT HUMAN ALPHA-INTERFERON - A PRELIMINARY-REPORT [J].
HOOFNAGLE, JH ;
MULLEN, KD ;
JONES, DB ;
RUSTGI, V ;
DIBISCEGLIE, A ;
PETERS, M ;
WAGGONER, JG ;
PARK, Y ;
JONES, EA .
NEW ENGLAND JOURNAL OF MEDICINE, 1986, 315 (25) :1575-1578
[10]   PROGRESSION OF HEPATITIS NON-A, NON-B TO CHRONIC ACTIVE HEPATITIS - HISTOLOGICAL FOLLOW-UP OF 2 CASES [J].
IWARSON, S ;
LINDBERG, J ;
LUNDIN, P .
JOURNAL OF CLINICAL PATHOLOGY, 1979, 32 (04) :351-355