INVITRO STUDIES OF HIV-1 INFECTION IN THYMIC LYMPHOCYTES - A PUTATIVE ROLE OF THE THYMUS IN AIDS PATHOGENESIS

被引：50

作者：

DEROSSI, A ^{[1
]}

CALABRO, ML ^{[1
]}

PANOZZO, M ^{[1
]}

BERNARDI, D ^{[1
]}

CARUSO, B ^{[1
]}

TRIDENTE, G ^{[1
]}

CHIECOBIANCHI, L ^{[1
]}

机构：

[1] UNIV VERONA,INST IMMUNOL SCI,I-37100 VERONA,ITALY

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1089/aid.1990.6.287

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To ascertain whether thymic lymphocytes represent suitable targets for HIV-1 infection, we infected thymic cell suspensions from normal donors with HIV-1 (HTLV-IIIB strain). We found that, in vitro, thymic lymphocytes are readily infected and highly permissive for HIV-1 replication. In addition, immature cells with the CD4+/CD8+ phenotype, most likely the precursors of mature circulating CD4+ and CD8+ lymphocytes, showed a marked susceptibility to viral infection and replication. These findings suggest that thymus infection may play a triggering role in the pathogenesis of AIDS, particularly in pediatric cases, and may partially explain the lack of restoration of peripheral CD4+ lymphocytes killed by HIV-1. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：287 / 298

页数：12

共 50 条

[21] Role of complement and Fc receptors in the pathogenesis of HIV-1 infection
David C. Montefiori
Springer Seminars in Immunopathology, 1997, 18 : 371 - 390
[22] Role of complement and Fc receptors in the pathogenesis of HIV-1 infection
Montefiori, DC
SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 1997, 18 (03): : 371 - 390
[23] Role of regulatory T cells in the pathogenesis of HIV-1 infection
Levy, Yves
RETROVIROLOGY, 2009, 6
[24] Role of regulatory T cells in the pathogenesis of HIV-1 infection
Yves Lévy
Retrovirology, 6
[25] MACROPHAGE-TROPIC HIV-1 VARIANTS - INITIATORS OF INFECTION AND AIDS PATHOGENESIS
SCHUITEMAKER, H
JOURNAL OF LEUKOCYTE BIOLOGY, 1994, 56 (03) : 218 - 224
[26] HOST AND HIV-1 VARIATION IN AIDS PATHOGENESIS
EDWARDS, M
JIAHSU, Y
NGUYEN, P
TRISTAN, M
PIZZUTI, A
CLEMENS, P
BURGER, H
WEISER, B
GIBBS, R
AMERICAN JOURNAL OF HUMAN GENETICS, 1991, 49 (04) : 406 - 406
[27] PATHOGENESIS OF HIV-1 INFECTION IN CHIMPANZEES
MURTHY, KK
COBB, EK
LUNCEFORD, SM
ROUSE, SR
JOHNSON, D
GALVAN, A
FASEB JOURNAL, 1995, 9 (04): : A1050 - A1050
[28] Productively infected CD8+lymphocytes in an AIDS patient: Implications for HIV-1 pathogenesis
Zerhouni, B
Zhang, JC
Saha, K
PEDIATRIC RESEARCH, 2000, 47 (04) : 281A - 281A
[29] Role of Viral Protein U (Vpu) in HIV-1 Infection and Pathogenesis
Khan, Nabab
Geiger, Jonathan D.
VIRUSES-BASEL, 2021, 13 (08):
[30] The Role of Estradiol and Progesterone in Mucosal HIV-1 Infection, Transmission and Pathogenesis
Peterson, Alison E.
Eszterhas, Susan K.
Howell, Alexandra L.
CURRENT WOMENS HEALTH REVIEWS, 2010, 6 (04) : 372 - 377

← 1 2 3 4 5 →