INVITRO STUDIES OF HIV-1 INFECTION IN THYMIC LYMPHOCYTES - A PUTATIVE ROLE OF THE THYMUS IN AIDS PATHOGENESIS

被引：50

作者：

DEROSSI, A ^{[1
]}

CALABRO, ML ^{[1
]}

PANOZZO, M ^{[1
]}

BERNARDI, D ^{[1
]}

CARUSO, B ^{[1
]}

TRIDENTE, G ^{[1
]}

CHIECOBIANCHI, L ^{[1
]}

机构：

[1] UNIV VERONA,INST IMMUNOL SCI,I-37100 VERONA,ITALY

来源：

AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1089/aid.1990.6.287

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

To ascertain whether thymic lymphocytes represent suitable targets for HIV-1 infection, we infected thymic cell suspensions from normal donors with HIV-1 (HTLV-IIIB strain). We found that, in vitro, thymic lymphocytes are readily infected and highly permissive for HIV-1 replication. In addition, immature cells with the CD4+/CD8+ phenotype, most likely the precursors of mature circulating CD4+ and CD8+ lymphocytes, showed a marked susceptibility to viral infection and replication. These findings suggest that thymus infection may play a triggering role in the pathogenesis of AIDS, particularly in pediatric cases, and may partially explain the lack of restoration of peripheral CD4+ lymphocytes killed by HIV-1. © 1990, Mary Ann Liebert, Inc. All rights reserved.

引用

页码：287 / 298

页数：12

共 44 条

[11] RECOMBINANT GENOMES WHICH EXPRESS CHLORAMPHENICOL ACETYLTRANSFERASE IN MAMMALIAN-CELLS [J].