INVITRO STUDIES OF HIV-1 INFECTION IN THYMIC LYMPHOCYTES - A PUTATIVE ROLE OF THE THYMUS IN AIDS PATHOGENESIS

被引：50
|
作者：
DEROSSI, A [1 ]
CALABRO, ML [1 ]
PANOZZO, M [1 ]
BERNARDI, D [1 ]
CARUSO, B [1 ]
TRIDENTE, G [1 ]
CHIECOBIANCHI, L [1 ]
机构：
[1] UNIV VERONA,INST IMMUNOL SCI,I-37100 VERONA,ITALY
来源：
AIDS RESEARCH AND HUMAN RETROVIRUSES | 1990年 / 6卷 / 03期
关键词：
D O I：
10.1089/aid.1990.6.287
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
To ascertain whether thymic lymphocytes represent suitable targets for HIV-1 infection, we infected thymic cell suspensions from normal donors with HIV-1 (HTLV-IIIB strain). We found that, in vitro, thymic lymphocytes are readily infected and highly permissive for HIV-1 replication. In addition, immature cells with the CD4+/CD8+ phenotype, most likely the precursors of mature circulating CD4+ and CD8+ lymphocytes, showed a marked susceptibility to viral infection and replication. These findings suggest that thymus infection may play a triggering role in the pathogenesis of AIDS, particularly in pediatric cases, and may partially explain the lack of restoration of peripheral CD4+ lymphocytes killed by HIV-1. © 1990, Mary Ann Liebert, Inc. All rights reserved.
引用
收藏
页码：287 / 298
页数：12
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