AGE-RELATED-CHANGES IN STRONTIUM TO CALCIUM RATIOS IN RAT-TISSUES

被引：6
|
作者：
SUGIHIRA, N
KOBAYASHI, E
SUZUKI, KT
机构：
[1] National Institute for Environmental Studies, Tsukuba, Ibaraki
来源：
BIOLOGICAL TRACE ELEMENT RESEARCH | 1990年 / 25卷 / 01期
关键词：
aging; effects of; calcium; discrimination; rat tissues; Strontium; strontium/calcium ratio;
D O I：
10.1007/BF02990267
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The Sr/Ca ratios in plasma, urine, bone, and soft tissues for various ages after weaning in male and female rats were determined to examine the effects of aging on the discrimination between strontium (Sr) and calcium (Ca) under physiological conditions. Age-related changes in the Sr/Ca ratios were similar in all tissues; the Sr/Ca ratios decreased rapidly until about 25-wk-old and then slowly, from that period on, reaching much lower values than in the diet. When the logarithm of the Sr/Ca ratio in each tissue was plotted against the logarithm of age, a linear relationship was observed with statistically significant (p<0.05) regression lines. The higher levels of Sr/Ca ratios in all tissues of the younger rats could be explained by the high efficiency of Sr absorption by the small intestine early in life. Parameters for the equations between age and Sr/Ca ratio differed with tissues, suggesting the existence of specific discrimination mechanisms in each tissue. © 1990 Humana Press Inc.
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收藏
页码：79 / 88
页数：10
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