THE MISUSE OF ANALYSIS OF VARIANCE TO DETECT SYNERGY IN COMBINATION-DRUG STUDIES

被引：24

作者：

CAUDLE, RM

WILLIAMS, GM

机构：

[1] Neurobiology and Anesthesiology Branch, National Institute of Dental Research, National Institutes of Health, Bethesda

来源：

PAIN | 1993年 / 55卷 / 03期

关键词：

ANALYSIS OF VARIANCE; SYNERGY; DOSE RESPONSE; ISOBOLOGRAPHIC ANALYSIS; STATISTICS;

D O I：

10.1016/0304-3959(93)90006-B

中图分类号：

R614 [麻醉学];

学科分类号：

100217 ;

摘要：

Drug combination studies often examine the possibility of synergy between drugs. Synergy is defined as an effect of a combination of drugs greater than that expected from the effects of the drugs given individually. One technique used by several investigators is the use of analysis of variance (ANOVA) to determine synergy. In this discussion, the argument is made that due to the pharmacology of drug combination studies the conditions necessary to support the use of ANOVA to detect synergy are typically not met. Therefore, the ANOVA technique is invalid for these drug combination studies.

引用

页码：313 / 317

页数：5

共 15 条

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