Synthesis and biological evaluation of new bis isatin derivatives for CNS activity

被引：0

作者：

Manchala, Lalitha ^{[1
]}

Tatipelly, Madhukar Reddy ^{[2
]}

Andole, Sowmya ^{[3
]}

Manda, Sarangapani ^{[1
]}

Devarakonda, Krishna Prasad ^{[3
]}

Arukula, Ravi ^{[4
]}

Gangarapu, Kiran ^{[3
]}

机构：

[1] Kakatiya Univ, Univ Coll Pharmaceut Sci, Warangal 506009, Telangana, India

[2] Kakatiya Inst Technol & Sci, Dept Phys Sci, Warangal 506015, Telangana, India

[3] Anurag Univ, Sch Pharm, Hyderabad 500088, Telangana, India

[4] Anurag Univ, Dept Chem, Hyderabad 500088, Telangana, India

来源：

MATERIALS TODAY-PROCEEDINGS | 2022年 / 64卷

关键词：

Isatins; Antioxidant activity; CNS activity;

D O I：

暂无

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Isatins are the important class of heterocyclic scaffolds which occupied a great role in the drug discovery. In the present study we synthesized Bis isatin derivatives(IIIa-f) and confirmed by physical and spectral data.compounds are evaluated for CNS activties (viz: gross behavioural study, locomotor activity, anticonvulsant activity) and antioxidant activty. We found that all the synthesised compounds are free from toxicity and toxic symptoms. Resulting pertaining to this study will be summerized in this paper. Compound IIIf (R = -OCH3) showed comparatively more anticonvulsant activity with 80% protection from MES induced convulsions compared to standard drug Phenytoin. All compounds have exhibited significant binding affinity against the glutamate receptor.Copyright (c) 2022 Elsevier Ltd. All rights reserved. Selection and peer-review under responsibility of the scientific committee of the International Conference on Advanced Materials for Innovation and Sustainability.

引用

页码：903 / 908

页数：6

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