Nucleosynthesis from non-thermal particles

The long-standing problem of nucleosynthesis from non-thermal charged particles is reviewed with emphasis on some novel points. Recent theoretical results predict very efficient acceleration of nuclei (up to GeV range) by violent systems with energy release in the form of multiple shock waves - OB associations and coronae of AGNs and black holes candidates in galactic accretion disks. A detection of gamma-line emission from the Orion complex by the COMPTEL telescope on board of GRO could confirm theoretical predictions. Production of lithium by non-thermal particles in Orion-Like objects is discussed. The mechanism can be responsible for the observed variations of abundance of isotopes.