INFLUENCES OF ROXITHROMYCIN ON CELL-MEDIATED IMMUNE-RESPONSES

被引：28

作者：

KONNO, S ^{[1
]}

ADACHI, M ^{[1
]}

ASANO, K ^{[1
]}

KAWAZOE, T ^{[1
]}

OKAMOTO, K ^{[1
]}

TAKAHASHI, T ^{[1
]}

机构：

[1] SHOWA UNIV, SCH MED, DEPT MED BIOL, SHINAGAWA KU, TOKYO 142, JAPAN

来源：

LIFE SCIENCES | 1992年 / 51卷 / 10期

关键词：

D O I：

10.1016/0024-3205(92)90493-9

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

We investigated the effects of roxithromycin (RXM), a synthesized macrolide antibiotic on murine cellular immune responses by examining the in vitro proliferative response of lymphocytes, interleukin 1 (IL-1) production and interleukin 2 (IL-2) production. RXM was orally administered to BALB/c mice at a dose of 5 mg/kg once a day for 42 days. Spontaneous blastic activity of lymphocytes prepared from mice administered with RXM for 7 days was higher than those from control mice. The activity peaked at the 14th day, and then decreased gradually to control levels by the 42nd day. Time kinetics of lymphocyte blastogenesis to concanavalin A showed a pattern similar to that observed in spontaneous blastic activity. Oral administration of RXM also influenced cytokine production; short-term (for 14 days) administration of RXM enhanced both IL-1 and IL-2 production but long-term (for 42 days) administration inhibited them.

引用

页码：PL107 / PL112

页数：6

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