STUDY OF CYCLIC KINETICS OF IMMUNITY BY MATHEMATICAL-MODELING METHODS

被引：0
作者：
SMIRNOVA, OA
机构：
来源：
KOSMICHESKAYA BIOLOGIYA I AVIAKOSMICHESKAYA MEDITSINA | 1991年 / 25卷 / 05期
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D O I：
暂无
中图分类号：
R1 [预防医学、卫生学];
学科分类号：
1004 ; 120402 ;
摘要：
The mathematical model of the dynamics of humoral immune responses to soluble antigens has been developed. This is a system of nonlinear differential equations describing concentrations of immunocompetent B-lymphocytes, plasma cells, antibodies and antigen. The model reproduces cyclic kinetics of the immune reaction to slowly catabolizing antigens which is observed experimentally. Within the framework of the model a description of the mechanism of origin of oscillatory modes of the dynamics of the immune response is presented. It has been shown that the feedback in the control of the antibody synthesis by antibodies is due to neutralization of the main stimulus of the immune system, i. e., free molecules of the antigen-by circulating antibodies.
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页码：53 / 56
页数：4
相关论文
共 11 条
  • [1] Bell G.I., 1973, Mathematical Biosci, V16, P291, DOI 10.1016/0025-5564(73)90036-9
  • [2] BRITTON S, 1968, J IMMUNOL, V100, P1326
  • [3] BYSTRYN JC, 1971, 1ST PROG IMM INT C I, P627
  • [4] CYCLIC KINETICS AND MATHEMATICAL EXPRESSION OF PRIMARY IMMUNE-RESPONSE TO SOLUBLE ANTIGEN .1. CYCLIC KINETICS OF IMMUNOGENESIS
    LEVI, MI
    DURIKHIN, KV
    BASOVA, NN
    SHMUTER, LM
    SUCHKOV, YG
    LIPNITSKII, AV
    GERASYUK, LG
    [J]. FOLIA MICROBIOLOGICA, 1973, 18 (03) : 229 - 236
  • [5] MOLLER E, 1968, REGULATION ANTIBODY, P141
  • [6] CYCLICAL APPEARANCE OF ANTIBODY-PRODUCING CELLS AFTER A SINGLE INJECTION OF SERUM-PROTEIN ANTIGEN
    ROMBALL, CG
    WEIGLE, WO
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1973, 138 (06) : 1426 - 1442
  • [7] SELL S, 1970, Journal of Immunology, V104, P483
  • [8] SKRYABIN AS, 1973, ZH MIKROB EPID IMMUN, P71
  • [9] SKRYABIN AS, 1968, ZH MIKROBIOL, P126
  • [10] SMIRNOVA OA, 1975, VESTNIK MOSKOVSKOGO, P485
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