PRESYNAPTIC AND POSTSYNAPTIC MODULATORS OF EXCITATORY NEUROTRANSMISSION - COMPARATIVE EFFECTS ON HYPOXIA/HYPOGLYCEMIA IN CORTICAL CULTURES

被引：26
作者：
KORETZ, B
AHERN, KV
WANG, N
LUSTIG, HS
GREENBERG, DA
机构：
[1] UNIV CALIF SAN FRANCISCO,DEPT NEUROL,SAN FRANCISCO,CA 94110
[2] SAN FRANCISCO GEN HOSP,SAN FRANCISCO,CA 94110
来源：
BRAIN RESEARCH | 1994年 / 643卷 / 1-2期
关键词：
AGATOXIN; CONOTOXIN; GLUTAMATE; HYPOGLYCEMIA; HYPOXIA; ISCHEMIA; N-METHYL-D-ASPARTATE; PRIMARY NEURONAL CULTURE;
D O I：
10.1016/0006-8993(94)90043-4
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Neuron-enriched cultures from embryonic rat cerebral cortex were exposed to hypoxia and hypoglycemia, and the resulting cellular injury was quantified by measuring lactate dehydrogenase (LDH) release, which was maximal after 20-24 h. The increase in LDH release produced by hypoxia/hypoglycemia was prevented by N-methyl-D-aspartate (NMDA) antagonists, but not by three classes of drugs thought to modulate glutamate release: Ca2+ channel antagonists (nimodipine, omega-conotoxin GVIA, omega-agatoxin-IVA), K-ATP channel activators (cromakalim, diazoxide), and glutamate transport inhibitors (dihydrokainate, DL-threo-beta-hydroxyaspartate).
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页码：334 / 337
页数：4
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