CATALYTIC ASYMMETRIC PREPARATION OF POLYFUNCTIONAL PROTECTED 1,2-DIOLS AND EPOXIDES

被引：44

作者：

EISENBERG, C ^{[1
]}

KNOCHEL, P ^{[1
]}

机构：

[1] UNIV MARBURG,FACHBEREICH CHEM,D-35032 MARBURG,GERMANY

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1994年 / 59卷 / 14期

关键词：

D O I：

10.1021/jo00093a005

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

alpha-Trialkylsiloxy aldehydes 4a,b add functionalized diorganozincs in the presence of catalytic amounts of (1R, 2R)-bis(trifluoromethanesulfonamido)-cyclohexane (8 mol%), affording protected 1,2-diols in 39-89% yield and 70-94% ee. The conversion of the monosilylated 1,2-diols to functionalized chiral epoxides has been demonstrated.

引用

页码：3760 / 3761

页数：2

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