LACK OF PROTECTIVE IMMUNITY AGAINST REINFECTION WITH HEPATITIS-C VIRUS

被引：645
作者：
FARCI, P
ALTER, HJ
GOVINDARAJAN, S
WONG, DC
ENGLE, R
LESNIEWSKI, RR
MUSHAHWAR, IK
DESAI, SM
MILLER, RH
OGATA, N
PURCELL, RH
机构：
[1] NIH,WARREN G MARGNUSON CLIN CTR,DEPT TRANSFUS MED,BETHESDA,MD 20892
[2] RANCHO LOS AMIGOS MED CTR,DOWNEY,CA 90242
[3] GEORGETOWN UNIV,DEPT MICROBIOL,DIV MOLEC VIROL & IMMUNOL,ROCKVILLE,MD 20852
[4] ABBOTT LABS,EXPTL BIOL RES,N CHICAGO,IL 60064
来源：
SCIENCE | 1992年 / 258卷 / 5079期
关键词：
D O I：
10.1126/science.1279801
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Some individuals infected with hepatitis C virus (HCV) experience multiple episodes of acute hepatitis. It is unclear whether these episodes are due to reinfection with HCV or to reactivation of the original virus infection. Markers of viral replication and host immunity were studied in five chimpanzees sequentially inoculated over a period of 3 years with different HCV strains of proven infectivity. Each rechallenge of a convalescent chimpanzee with the same or a different HCV strain resulted in the reappearance of viremia, which was due to infection with the subsequent challenge virus. The evidence indicates that HCV infection does not elicit protective immunity against reinfection with homologous or heterologous strains, which raises concerns for the development of effective vaccines against HCV.
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页码：135 / 140
页数：6
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