ROLE OF NA-K PUMP POTASSIUM REGULATION AND IPSPS IN SEIZURES AND SPREADING DEPRESSION IN IMMATURE RABBIT HIPPOCAMPAL SLICES

被引:156
作者
HAGLUND, MM
SCHWARTZKROIN, PA
机构
[1] UNIV WASHINGTON,DEPT NEUROL SURG,RI-20,SEATTLE,WA 98195
[2] UNIV WASHINGTON,DEPT PHYSIOL & BIOPHYS,SEATTLE,WA 98195
关键词
D O I
10.1152/jn.1990.63.2.225
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Using the immature (8-12 days postnatal) rabbit hippocampal slice preparation, we investigated regional extracellular potassium concentration ([K+)(o)) changes that occur during spontaneous and evoked spreading depression (SD) episodes. We report here a difference between the CA1 and CA3 cell populations in the immature hippocampus with regard to 1) resting [K+](o), 2) magnitude of the [K+](o) change during seizurelike events and SDs, and 3) susceptibility to SD episodes. Experiments were also performed to elucidate the roles that the Na-K pump and synaptic inhibition play in controlling SD onset, duration, and recovery. We demonstrated a major role for potassium regulation by the Na-K pump and a lesser modulatory role for inhibitory postsynaptic potentials (IPSPs) in preventing SD in the CA3 region.
引用
收藏
页码:225 / 239
页数:15
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