REGULATION OF PHOSPHOFRUCTOKINASE BY PHOSPHOCREATINE AND PHOSPHORYLATED GLYCOLYTIC INTERMEDIATES

被引：129

作者：

KRZANOWS.J

MATSCHIN.FM

机构：

[1] Department of Pharmacology Washington University School of Medicine St. Louis

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1969年 / 34卷 / 06期

关键词：

D O I：

10.1016/0006-291X(69)90253-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

P-fructokinase from brain and muscle is inhibited invitro by P-creatine, 3-P-glycerate, P-enolpyruvate, 2-P-glycerate and 2,3-P2-glycerate. This inhibition is most pronounced at neutral pH, in the presence of inhibitory levels of ATP and of essentially non-activating levels of fructose-6-P. Evidence found in the literature suggests that inhibition invitro of P-fructokinase by these compounds plays a role in regulation of glycolysis. © 1969.

引用

页码：816 / &

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