PREPARATION OF TRISULFIDE DERIVATIVES OF CYSTINE AND THEIR FORMATION AS BY-PRODUCTS DURING PEPTIDE-SYNTHESIS

被引：13

作者：

PARMENTIER, B ^{[1
]}

MOUTIEZ, M ^{[1
]}

TARTAR, A ^{[1
]}

SERGHERAERT, C ^{[1
]}

机构：

[1] INST PASTEUR,CNRS,CHIM BIOMOLEC SERV,F-59019 LILLE,FRANCE

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 21期

关键词：

D O I：

10.1016/S0040-4039(00)73228-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The formation of a trisulfide derivative is observed when di-NH2-protected cystine, is used during peptide synthesis. This side reaction occurs during the coupling step with several coupling reagents. A convenient method for the preparation of these derivatives in mild conditions is described

引用

页码：3531 / 3534

页数：4

共 7 条

[1] PHOTOCHEMICAL DEGRADATION OF CYSTINE IN AQUEOUS SOLUTION IN PRESENCE OF AIR [J].

ASQUITH, RS ;

HIRST, L .

BIOCHIMICA ET BIOPHYSICA ACTA, 1969, 184 (02) :345-&

[2] SYNTHESIS OF N-BENZYLOXYCARBONYL-L-CYSTEINYLGLYCINE 3-DIMETHYLAMINOPROPYLAMIDE DISULFIDE - A CHEAP AND CONVENIENT NEW ASSAY FOR TRYPANOTHIONE REDUCTASE [J].

ELWAER, A ;

DOUGLAS, KT ;

SMITH, K ;

FAIRLAMB, AH .

ANALYTICAL BIOCHEMISTRY, 1991, 198 (01) :212-216

[3] OCCURRENCE OF BIS-(2-AMINO-2-CARBOXYETHYL) TRISULPHIDE IN HYDROLYSATES OF WOOL AND OTHER PROTEINS [J].

FLETCHER, JC ;

ROBSON, A .

BIOCHEMICAL JOURNAL, 1963, 87 (03) :553-+

[4] MAC-MASS, A SOFTWARE DEDICATED TO MASS-SPECTROMETRY OF SYNTHETIC PEPTIDES [J].

GESQUIERE, JC ;

TARTAR, A .

ANALYTICAL BIOCHEMISTRY, 1993, 215 (02) :299-302

[5] NEW METHODOLOGY FOR THE INTRODUCTION OF SULFUR INTO ORGANIC-MOLECULES - SYNTHESIS OF ANHYDROUS LI2S, LI2S2 AND LISR SPECIES BY LITHIUM TRIETHYLBOROHYDRIDE REDUCTION OF ELEMENTAL SULFUR AND DISULFIDES [J].

GLADYSZ, JA ;

WONG, VK ;

JICK, BS .

TETRAHEDRON, 1979, 35 (20) :2329-2335

[6] A CONVENIENT SYNTHESIS OF SYMMETRICAL DISULFIDES [J].

HASE, TA ;

PERAKYLA, H .

SYNTHETIC COMMUNICATIONS, 1982, 12 (12) :947-950

[7] CHARACTERIZATION OF A TRISULFIDE DERIVATIVE OF BIOSYNTHETIC HUMAN GROWTH-HORMONE PRODUCED IN ESCHERICHIA-COLI [J].

JESPERSEN, AM ;

CHRISTENSEN, T ;

KLAUSEN, NK ;

NIELSEN, PF ;

SORENSEN, HH .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 1994, 219 (1-2) :365-373

← 1 →