GENETIC-CHARACTERIZATION OF A FAMILIAL NONSPECIFIC DEMENTIA ORIGINATING IN JUTLAND, DENMARK

被引:11
作者
BROWN, J
GYDESEN, S
SORENSEN, SA
BRUN, A
SMITH, S
HOULDEN, H
TWELLS, R
MULLAN, M
ROSSOR, M
COLLINGE, J
PALMER, M
GOATE, A
HARDY, J
机构
[1] UNIV COPENHAGEN,PANUM INST,INST MED GENET,DK-2200 COPENHAGEN,DENMARK
[2] UNIV LUND HOSP,DEPT NEUROPATHOL,S-22185 LUND,SWEDEN
[3] ST MARYS HOSP,DEPT NEUROL,LONDON W2 1NF,ENGLAND
关键词
FRONTAL LOBE DEMENTIA; NONSPECIFIC DEMENTIA; PICKS DISEASE; PRION DISEASE; FAMILIAL DEMENTIA; MICROSATELLITE PROBES; LINKAGE ANALYSIS;
D O I
10.1016/0022-510X(93)90288-A
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Dementias with non-specific pathological changes are a relatively common but under diagnosed form of presenile dementia. A high proportion of reported cases are familial. We report on molecular genetic findings in the largest known pedigree with this syndrome. We have excluded the mutations known to cause familial prion disease, APP-linked familial Alzheimer's disease and candidate regions for Huntington's disease, other forms of Alzheimer's disease and motor neuron disease. We have demonstrated that familial non-specific dementia is a novel genetic dementia.
引用
收藏
页码:138 / 143
页数:6
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