THE ACTIVITY OF DIPEPTIDYL PEPTIDASE-II AND DIPEPTIDYL PEPTIDASE-IV IN MICE IMMUNIZED WITH TYPE-II COLLAGEN

被引：6
|
作者：
FUJITA, K
HAGIHARA, M
NAGATSU, T
IWATA, H
MIURA, T
机构：
[1] FUJITA HLTH UNIV,SCH MED,INST COMPREHENS MED SCI,KUTSUKAKECHOU,TOYOAKE 47011,JAPAN
[2] NAGOYA UNIV,SCH MED,DEPT BIOCHEM,SHOWA KU,NAGOYA,AICHI 466,JAPAN
[3] NAGOYA UNIV,SCH MED,DEPT ORTHOPED SURG,SHOWA KU,NAGOYA,AICHI 466,JAPAN
来源：
BIOCHEMICAL MEDICINE AND METABOLIC BIOLOGY | 1992年 / 48卷 / 03期
关键词：
D O I：
10.1016/0885-4505(92)90069-B
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
We investigated the activity of peptidases in the serum of mice with experimental polyarthritis that was induced by the injection of type II collagen, an experimental model of human rheumatoid arthritis. The activity of dipeptidyl peptidase II (DPP II) was increased and that of dipeptidyl peptidase IV (DPP IV) was decreased resulting in the significant increase of the serum DPP II DPP IV ratio in the polyarthritic mice compared with that of controls. These results indicate that the DPP II DPP IV ratio is a novel index of disease activity in mice with collagen-induced polyarthritis and may be useful in assessing the activity of rheumatoid arthritis in humans. © 1992.
引用
收藏
页码：227 / 234
页数：8
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