Guanine nucleotide exchange factor H1 can be a new biomarker of melanoma

被引：3

作者：

Shi, Jie ^{[1
]}

Guo, Bingyu ^{[1
]}

Zhang, Yu ^{[1
]}

Hui, Qiang ^{[1
]}

Chang, Peng ^{[1
]}

Tao, Kai ^{[1
]}

机构：

[1] Gen Hosp Shenyang Mil Reg, Plast & Reconstruct Surg, 83 Wenhua Rd, Shenyang 110016, Liaoning, Peoples R China

来源：

BIOLOGICS-TARGETS & THERAPY | 2016年 / 10卷

关键词：

GEF-H1; melanoma; biomarker; proliferation; metastasis;

D O I：

10.2147/BTT.S109643

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Guanine nucleotide exchange factor H1 (GEF-H1), which couples microtubule dynamics to RhoA activation, is a microtubule-regulated exchange factor. Studies have shown that GEF-H1 can be involved in various cancer pathways; however, the clinical significance of GEF-H1 expression and functions in melanoma has not been established. In this study, we investigated the relationship between clinical outcomes and GEF-H1 functions in melanoma. A total of 60 cases of different grades of melanoma samples were used to detect the expression of GEF-H1. Results showed that both messenger RNA and protein levels of GEF-H1 were significantly higher in high-grade melanomas. Furthermore, patients with high GEF-H1 expression had a shorter overall survival (22 months) than patients with low level of GEF-H1 expression (33.38 months). We also found that GEF-H1 can promote the proliferation and metastasis of melanoma cells. In summary, these results suggested that GEF-H1 may be a valuable biomarker for assessing the degree and prognosis of melanoma following surgery.

引用

页码：89 / 98

页数：10

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