[2+2]CYCLOADDITION OF TRICHLOROACETYL ISOCYANATE TO FURANOID GLYCALS

被引：10
|
作者：
ABRAMSKI, W [1 ]
BADOWSKAROSLONEK, K [1 ]
CHMIELEWSKI, M [1 ]
机构：
[1] POLISH ACAD SCI,INST ORGAN CHEM,PL-01224 WARSAW,POLAND
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 11期
关键词：
D O I：
10.1016/S0960-894X(01)80964-1
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Reaction between furanoid glycals 1-3 and trichloroacetyl isocyanate yielded a mixture of [2+2] and [4+2]cycloadducts. The isocyanate entered a glycal molecule exclusively anti with respect to the substituent at the C-3 carbon atom. Deprotection of the nitrogen atom in the [2+2]cycloadduct produced stable bicyclic B-lactams 10-12.
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收藏
页码：2403 / 2404
页数：2
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