LOCAL CEREBRAL GLUCOSE-UTILIZATION IN RATS WITH DECEREBRATE RIGIDITY AND EFFECTS OF CENTRALLY ACTING MUSCLE-RELAXANTS, DIAZEPAM AND TIZANIDINE

被引：0
|
作者：
NAKAMURA, T
ONO, H
FUKUDA, H
TANABE, M
KOZUKA, M
IWATA, N
机构：
[1] UNIV TOKYO, FAC PHARMACEUT SCI, BUNKYO KU, TOKYO 113, JAPAN
[2] NIHON UNIV, COLL PHARM, FUNABASHI, CHIBA 274, JAPAN
[3] SANKYO CO LTD, NEW LEAD RES LABS, SHINAGAWA KU, TOKYO 140, JAPAN
来源：
BIOLOGICAL & PHARMACEUTICAL BULLETIN | 1993年 / 16卷 / 01期
关键词：
DECEREBRATE RIGIDITY; LOCAL CEREBRAL GLUCOSE UTILIZATION; TIZANIDINE; DIAZEPAM;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Local cerebral glucose utilization (LCGU) was investigated in rats with decerebrate rigidity using the [C-14]2-deoxyglucose (2DG) method in order to identify the site responsible for the rigidity. LCGU was increased in the medial vestibular nucleus, the fastigial nucleus, the interpositus nucleus and the dentate nucleus during decerebrate rigidity. Diazepam and tizanidine, centrally acting muscle relaxants, reduced the increase of LCGU in the vestibular and cerebellar nuclei. These results suggest that the vestibular and cerebellar nuclei are the possible sites responsible for the development of decerebrate rigidity and the action of some centrally acting muscle relaxants.
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页码：33 / 35
页数：3
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