BINDING BEHAVIOR OF ANTIBODIES REACTING SPECIFICALLY WITH AN IMMUNODOMINANT REGION OF THE TRANSMEMBRANE PROTEIN GP41 OF HIV-1

被引：4
|
作者：
DOPEL, SH [1 ]
PORSTMANN, T [1 ]
GRUNOW, R [1 ]
HENKLEIN, P [1 ]
PAS, P [1 ]
VONBAEHR, R [1 ]
机构：
[1] HUMBOLDT UNIV,BEREICH MED CHARITE,SCH MED,DEPT PHARMACOL,O-1040 BERLIN,GERMANY
来源：
JOURNAL OF VIROLOGICAL METHODS | 1990年 / 28卷 / 02期
关键词：
Anti-HIV ELISA; HIV; Synthetic peptide; Transmembrane protein gp41;
D O I：
10.1016/0166-0934(90)90034-D
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
A highly conserved region of the transmembrane protein gp41 of the HIV-1 was found in which the amino acid sequence 606 to 620 was characterized as an immunodominant region. The binding behaviours of a human monoclonal antibody and of polyclonal specific antibodies in sera of HIV-infected persons to this particular sequence have been studied. In two sandwich-type ELISAs with synthetic peptides as antigen representing this region, sera of 312 HIV-infected persons at all stages could be clearly discriminated against 500 anti-HIV antibody negative sera of healthy blood donors. © 1990.
引用
收藏
页码：189 / 198
页数：10
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