MAPPING OF HUMAN-CHROMOSOME 22 WITH A PANEL OF SOMATIC-CELL HYBRIDS

被引：75

作者：

DELATTRE, O

AZAMBUJA, CJ

AURIAS, A

ZUCMAN, J

PETER, M

ZHANG, F

HORSCAYLA, MC

ROULEAU, G

THOMAS, G

机构：

[1] INST CURIE,26 RUE DULM,F-75231 PARIS 05,FRANCE

[2] INST INVEST BIOL CLEMENTE ESTABLE,MONTEVIDEO,URUGUAY

[3] HOP ENFANTS MALAD,INSERM,U12,F-75730 PARIS 04,FRANCE

[4] MCGILL UNIV,MONTREAL GEN HOSP,DEPT NEUROL,MONTREAL H3G 1A4,QUEBEC,CANADA

[5] INST CURIE,CNRS,URA 620,F-75231 PARIS 05,FRANCE

来源：

GENOMICS | 1991年 / 9卷 / 04期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0888-7543(91)90366-M

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The adenylosuccinate lyase (ADSL) which is essential for generating adenylate, maps to the long arm of chromosome 22. By using a Chinese hamster ovary cell line deficient in ADSL activity, we have constructed a set of 17 somatic cell hybrids containing defined regions of human chromosome 22. This panel was extended with six additional hybrids, obtained in other laboratories using various methods of selection. Southern analysis of the hybrids with 38 chromosome 22 probes defined 14 different subregions which could be linearly organized on the long arm of chromosome 22. The order of the probes thus deduced is fully compatible with their previous localization and with the genetic map. The ADSL gene was further sublocalized between the MB and D22S22. This panel, which enables the rapid assignment of chromosome 22 single copy probes to small subregions, will be an important tool in the construction of a detailed physical map of this part of the genome. © 1991.

引用

页码：721 / 727

页数：7

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