INOTROPIC EFFECTS OF ETHANOL ON THE ISOLATED PAPILLARY-MUSCLE OF THE DIABETIC RAT

被引:26
作者
BROWN, RA
ROBINSON, E
DUNBAR, JC
机构
[1] Department of Physiology, Wayne State University, School of Medicine, Detroit, MI
关键词
ETHANOL; PAPILLARY MUSCLE; INOTROPISM; MYOCARDIUM; FORCE OF CONTRACTION; DIABETES-MELLITUS;
D O I
10.1016/0741-8329(93)90041-L
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
The present study was designed to characterize the inotropic effects of ethanol (ETOH) on diabetic rat heart. Left-ventricular papillary muscles, from normal and diabetic (streptozotocin, 50 mg/kg IV; 6 weeks) rats, were superfused with Tyrode's solution at 30 oC while driven at 0.5 Hz. Developed tension, time-to-peak tension (TPT), time-to-90% relaxation (RT90), maximum rate of tension developed (+ VT) and maximum rate of tension fall (-VT) were determined in the absence and presence of clinically relevant concentrations of ETOH (80-240 mg/dl, i.e., 1.7-5.2 mM). Ethanol decreased developed tension, TPT, RT90, and VT in papillary muscles from both groups. Ethanol 80 mg/dl reduced tension, + VT and - VT in preparations from diabetic animals. However, this concentration had no effect on normal muscles. An intermediate concentration of ETOH (120 mg/dl), decreased tension and +VT in preparations from both groups, whereas a higher dose (240 mg/dl) decreased tension, TPT, RT90, VT, and - VT, and induced spontaneous contractures in both groups. The negative inotropic effects of ethanol were generally concentration-dependent and the diabetic myocardium maybe more sensitive to inotropic effects of clinically relevant concentrations of ETOH. Ethanol-induced diminution in contractile tension in normal and diabetic myocardium is associated with reduced contraction and relaxation velocity as well as their respective duration.
引用
收藏
页码:231 / 235
页数:5
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