EFFECT OF CLOFIBRATE ON THE PHOSPHOLIPID BIOSYNTHESIS IN RAT-LIVER

被引：2
|
作者：
CATALAN, RE [1 ]
CASTILLON, MP [1 ]
PRIEGO, JG [1 ]
机构：
[1] DEPT INVEST,LAB ALTER,MATEO INURRIA 30,MADRID 16,SPAIN
来源：
EXPERIENTIA | 1979年 / 35卷 / 07期
关键词：
D O I：
10.1007/BF01955111
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The effect of clofibrate on rat liver phospholipid biosynthesis was studied using32P as a precursor. Phospholipid classes, levels and specific radioactivity were evaluated. Significant increases in levels of phosphatidylethanolamine and phosphatidylcholine were found and could account for the observed increase in total phospholipids. Specific activity of phosphatidylserine increased and that of phosphatidylethanolamine decreased. This fact suggests that clofibrate seems to alter the systems engaged in the transformation occurring within the different classes of phospholipids but not the de novo biosynthesis. © 1979 Birkhäuser Verlag.
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页码：859 / 860
页数：2
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