HUMAN-LYMPHOCYTE FC RECEPTOR FOR IGE - SEQUENCE HOMOLOGY OF ITS CLONED CDNA WITH ANIMAL LECTINS

被引：246
作者：
IKUTA, K
TAKAMI, M
KIM, CW
HONJO, T
MIYOSHI, T
TAGAYA, Y
KAWABE, T
YODOI, J
机构：
[1] KYOTO UNIV, SCH MED, DEPT MED CHEM, KYOTO 606, JAPAN
[2] KYOTO UNIV, SCH MED, INST IMMUNOL, KYOTO 606, JAPAN
来源：
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1987年 / 84卷 / 03期
关键词：
D O I：
10.1073/pnas.84.3.819
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
We have purified the human lymphocyte Fc receptor specific for IgE (Fc.epsilon. receptor) and its soluble form by using the anti-Fc.epsilon. receptor monoclonal antibody H107. Using an oligonucleotide probe corresponding to the partial amino acid sequence of the soluble Fc.epsilon. receptor related to IgE binding factor, we cloned, sequenced, and expressed a cDNA for the receptor. The Fc.epsilon. receptor has 321 amino acid residues with no NH2-terminal signal sequence. The receptor was separated into two domains by a putative 24-amino acid residue transmembrane region located near the NH2-terminal end. The Fc.epsilon. receptor showed a marked homology with animal lectins including human and rat asialoglycoprotein receptors, chicken hepatic lectin, and rat mannose binding proteins.
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页码：819 / 823
页数：5
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