EFFECT OF NGF ANTIBODIES ON MAST-CELL DISTRIBUTION, HISTAMINE AND SUBSTANCE-P LEVELS IN THE KNEE-JOINT OF TNF ARTHRITIC TRANSGENIC MICE

被引：18

作者：

ALOE, L ^{[1
]}

PROBERT, L ^{[1
]}

KOLLIAS, G ^{[1
]}

MICERA, A ^{[1
]}

TIRASSA, P ^{[1
]}

机构：

[1] HELLEN INST PASTEUR, MOLEC GENET LAB, ATHENS, GREECE

来源：

RHEUMATOLOGY INTERNATIONAL | 1995年 / 14卷 / 06期

关键词：

TRANSGENIC MOUSE; NERVE GROWTH FACTOR; NGF ANTIBODIES; TUMOR NECROSIS FACTOR; MAST CELLS;

D O I：

10.1007/BF00262091

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-alpha (TNF-alpha) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammatory markers in joint arthritis.

引用

页码：249 / 252

页数：4

共 26 条

[1] THE SYNOVIUM OF TRANSGENIC ARTHRITIC MICE EXPRESSING HUMAN TUMOR-NECROSIS-FACTOR CONTAINS A HIGH-LEVEL OF NERVE GROWTH-FACTOR [J].